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44 Moreover, anergic cells Usually retain the next susceptibility to apoptosis Unless of course anti-apoptotic proteins for example BCL2 are overexpressed, as is the situation for CLL cells.forty five Certainly, most main therapeutic advancements occurring in the last decade are related to the inhibition of BCR and BCL2-mediated signaling.
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44 Furthermore, anergic cells normally keep a greater susceptibility to apoptosis unless anti-apoptotic proteins such as BCL2 are overexpressed, as is the case for CLL cells.forty five In truth, most significant therapeutic advancements transpiring in the last decade are associated with the inhibition of BCR and BCL2-mediated signaling.
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See "Targeted therapies in CLL: mechanisms of resistance and strategies for administration" on page 471.
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